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Title: Dimensionality of rolled-up nanomembranes controls neural stem cell migration mechanism
Authors: Koch, BrittaMeyer, Anne K.Helbig, LindaHarazim, Stefan M.Storch, AlexanderSanchez, SamuelSchmidt, Oliver G.
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Issue Date: 2015
Published in: Nano Letters, Volume 15, Issue 8, Page 5530-5538
Publisher: Washington D.C. : American Chemical Society
Abstract: We employ glass microtube structures fabricated by rolledup nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode transition. Space restrictions preset by the diameter of nanomembrane topography modify the cell shape toward characteristics found in living tissue. We demonstrate the importance of substrate dimensionality for the migration mode of NSCs and thereby define rolled-up nanomembranes as the ultimate tool for single-cell migration studies.
Keywords: Nanomembranes; rolled-up nanotechnology; 3D cell culture scaffold; spatial confinement; neural stem cells; cell migration
DDC: 620
License: CC BY 3.0 Unported
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