Please use this identifier to cite or link to this item: https://oar.tib.eu/jspui/handle/123456789/4760
Title: Super-resolution fluorescence microscopy studies of human immunodeficiency virus
Authors: Chojnacki, JeremyEggeling, Christian
Publishers Version: https://doi.org/10.1186/s12977-018-0424-3
Issue Date: 2018
Published in: Retrovirology 15 (2018), Nr. 41
Publisher: London : BioMed Central
Abstract: Super-resolution fluorescence microscopy combines the ability to observe biological processes beyond the diffraction limit of conventional light microscopy with all advantages of the fluorescence readout such as labelling specificity and non-invasive live-cell imaging. Due to their subdiffraction size (< 200 nm) viruses are ideal candidates for super-resolution microscopy studies, and Human Immunodeficiency Virus type 1 (HIV-1) is to date the most studied virus by this technique. This review outlines principles of different super-resolution techniques as well as their advantages and disadvantages for virological studies, especially in the context of live-cell imaging applications. We highlight the findings of super-resolution based HIV-1 studies performed so far, their contributions to the understanding of HIV-1 replication cycle and how the current advances in super-resolution microscopy may open new avenues for future virology research.
Keywords: Human immunodeficiency virus; HIV-1; Super-resolution microscopy; Nanoscopy; Fluorescence
DDC: 610
License: CC BY 4.0 Unported
Link to License: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:Ingenieurwissenschaften



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