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Title: Anti-Staphylococcal Humoral Immune Response in patients with chronic rhinosinusitis
Authors: Thunberg, UlricaHugosson, SvanteFredlund, HansCao, YangEhricht, RalfMonecke, StefanMueller, ElkeEngelmann, SusanneSöderquist, Bo
Publishers Version: https://doi.org/10.4193/RHINOL/19.002
Issue Date: 2019
Published in: Rhinology online 2 (2019)
Publisher: Amsterdam : European Rhinologic Society
Abstract: Background: Staphylococcus aureus (S. aureus) can behave both as a harmless commensal and as a pathogen. Its significance in the pathogenesis of chronic rhinosinusitis (CRS) is not yet fully understood. This study aimed to determine serum antibody responses to specific staphylococcal antigens in patients with CRS and healthy controls, and to investigate the correlation between specific antibody response and severity of symptoms. Methodology: Serum samples from 39 patients with CRS and 56 healthy controls were analysed using a protein microarray to investigate the antibody response to S. aureus specific antigens, with a focus on immunoglobulin G (IgG) directed toward staphylococcal components accessible to the immune system. Holm-Bonferroni corrections were applied in all analyses. Information about growth of S. aureus in nares and maxillary sinus was taken from a previous study based on the same individuals. Clinical symptoms were assessed using a scoring system. Results: IgG antibody levels toward staphylococcal TSST-1 and LukF-PV were significantly higher in the CRS patient group compared to healthy controls, and levels of anti-TSST-1 antibodies were significantly higher in the CRS patient group with S. aureus in maxillary sinus than in controls. There were no correlations between the severity of symptoms and levels of serum anti-staphylococcal IgG antibody levels for LukF-PV and TSST-1. Conclusions: TSST-1 and LukF-PV could be interesting markers for future studies of the pathogenesis of CRS.
Keywords: antibodies; chronic rhinosinusitis; immunoglobulin; G; protein microarray; staphylococcal antigen
DDC: 610
License: CC BY 4.0 Unported
Link to License: https://creativecommons.org/licenses/by/4.0/
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