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Title: Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles
Authors: Piché, DominiqueTavernaro, IsabellaFleddermann, JanaLozano, Juan G.Varambhia, AakashMaguire, Mahon L.Koch, MarcusUkai, TomofumiHernández Rodríguez, Armando J.Jones, LewysDillon, FrankReyes Molina, IsraelMitzutani, MaiGonzález Dalmau, Evelio R.Maekawa, ToruNellist, Peter D.Kraegeloh, AnnetteGrobert, Nicole
Publishers Version:
Issue Date: 2019
Published in: ACS Applied Materials & Interfaces 11 (2019)
Publisher: Washington, DC : American Chemical Society
Abstract: Extraordinarily small (2.4 nm) cobalt ferrite nanoparticles (ESCIoNs) were synthesized by a one-pot thermal decomposition approach to study their potential as magnetic resonance imaging (MRI) contrast agents. Fine size control was achieved using oleylamine alone, and annular dark-field scanning transmission electron microscopy revealed highly crystalline cubic spinel particles with atomic resolution. Ligand exchange with dimercaptosuccinic acid rendered the particles stable in physiological conditions with a hydrodynamic diameter of 12 nm. The particles displayed superparamagnetic properties and a low r2/r1 ratio suitable for a T1 contrast agent. The particles were functionalized with bile acid, which improved biocompatibility by significant reduction of reactive oxygen species generation and is a first step toward liver-targeted T1 MRI. Our study demonstrates the potential of ESCIoNs as T1 MRI contrast agents.
Keywords: cobalt ferrite nanoparticles; one-pot synthesis; magnetic resonance imaging; ligand exchange; cytotoxicity; ultrasmall nanoparticles; T1-weighted contrast agent; liver targeting
DDC: 540
License: CC BY 4.0 Unported
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