Please use this identifier to cite or link to this item: https://oar.tib.eu/jspui/handle/123456789/4881
Files in This Item:
File SizeFormat 
Li et al 2018, Copper.pdf665,49 kBAdobe PDFView/Open
Title: Copper/iron co-catalyzed alkoxycarbonylation of unactivated alkyl bromides
Authors: Li, Y.Wu, X.-F.
Publishers Version: https://doi.org/10.1038/s42004-018-0039-6
Issue Date: 2018
Published in: Communications Chemistry Vol. 1 (2018), No. 1
Publisher: London : Springer Nature
Abstract: Carbonylative transformations of alkyl bromides have been explored less than those of aryl halides, in part because of the high barrier to activation of aryl bromides. Additionally, alkyl-metal reagents formed in situ can tend to undergo β-hydride elimination. Here we describe a copper/iron co-catalyzed alkoxycarbonylation of unactivated alkyl bromides. In the presence of catalytic quantities of iron and copper catalysts, primary, secondary, and tertiary alkyl bromides are carbonylatively transformed into the corresponding aliphatic esters in good yields. A potential reaction mechanism is proposed based on control experiments.
Keywords: Carbonylative transformations; alkyl bromides; alkoxycarbonylation
DDC: 540
License: CC BY 4.0 Unported
Link to License: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:Chemie



This item is licensed under a Creative Commons License Creative Commons