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Title: Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release
Authors: Xu, H.Medina-Sánchez, M.Schmidt, O.G.
Publishers Version:
Issue Date: 2020
Published in: Angewandte Chemie - International Edition Vol. 59 (2020), No. 35
Publisher: Weinheim : Wiley-VCH Verlag
Abstract: An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captured within the HA microflake, the assembly is trapped and transported by a magnetically-driven helical microcarrier. The trapping of the sperm-microflake occurs by a local vortex induced by the microcarrier during rotation-translation under a rotating magnetic field. After transport, the microflake is enzymatically hydrolyzed by local proteases, allowing sperm to escape and finally reach the target location. This cargo-delivery system represents a new concept to transport not only multiple motile sperm but also other actively moving biological cargoes.
Keywords: enzymatic release; mature sperm selection; microflake synthesis; micromotor; sperm swarm transport; Controlled drug delivery; Hyaluronic acid; Micromotors; Binding mechanisms; Cargo delivery; Integrated systems; Magnetic micromotors; Microcarriers; Reproductive systems; Rotating magnetic fields; Target location; Targeted drug delivery
DDC: 540
License: CC BY-NC 4.0 Unported
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Appears in Collections:Chemie

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