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Riedl et al 2014, Cardio-Respiratory Coordination Increases.pdf1.77 MBAdobe PDFView/Open
Title: Cardio-respiratory coordination increases during sleep apnea
Authors: Riedl, M.Müller, A.Kraemer, J.F.Penzel, T.Kurths, J.Wessel, N.
Publishers Version: https://doi.org/10.1371/journal.pone.0093866
Issue Date: 2014
Published in: PLoS ONE Vol. 9 (2014), No. 4
Publisher: San Francisco, CA : Public Library of Science (PLoS)
Abstract: Cardiovascular diseases are the main source of morbidity and mortality in the United States with costs of more than $170 billion. Repetitive respiratory disorders during sleep are assumed to be a major cause of these diseases. Therefore, the understanding of the cardio-respiratory regulation during these events is of high public interest. One of the governing mechanisms is the mutual influence of the cardiac and respiratory oscillations on their respective onsets, the cardiorespiratory coordination (CRC). We analyze this mechanism based on nocturnal measurements of 27 males suffering from obstructive sleep apnea syndrome. Here we find, by using an advanced analysis technique, the coordigram, not only that the occurrence of CRC is significantly more frequent during respiratory sleep disturbances than in normal respiration (p-value<10-51) but also more frequent after these events (p-value<10-15). Especially, the latter finding contradicts the common assumption that spontaneous CRC can only be observed in epochs of relaxed conditions, while our newly discovered epochs of CRC after disturbances are characterized by high autonomic stress. Our findings on the connection between CRC and the appearance of sleep-disordered events require a substantial extension of the current understanding of obstructive sleep apneas and hypopneas.
Keywords: article; autonomic nervous system; breathing pattern; cardiorespiratory coordination; cardiovascular function; clinical article; coordination; human; male; mental stress; oscillation; REM sleep; respiration control; signal detection; sleep disordered breathing; adult; biological model; breathing rate; Cardiovascular Diseases; complication; heart rate; pathophysiology; physiology; sleep disordered breathing; sleep stage; Adult; Autonomic Nervous System; Cardiovascular Diseases; Heart Rate; Humans; Male; Models, Cardiovascular; Respiratory Rate; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Sleep Stages
DDC: 610
License: CC BY 4.0 Unported
Link to License: https://creativecommons.org/licenses/by/4.0/
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