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Title: Towards dynamical network biomarkers in neuromodulation of episodic migraine
Authors: Dahlem, M.A.Rode, S.May, A.Fujiwara, N.Hirata, Y.Aihara, K.Kurths, J.
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Issue Date: 2013
Published in: Translational Neuroscience Vol. 4 (2013), No. 3
Publisher: Berlin : De Gruyter
Abstract: Computational methods have complemented experimental and clinical neurosciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine.
Keywords: Biomarkers; Central pattern generator; Hodgkin-Huxley models; Migraine; Neuromodulation; Nonlinear dynamics; Pain; Spreading depression; biological marker; dynamical network biomarker; potassium ion; sodium ion; unclassified drug; brain ischemia; central pattern generator; channel gating; chronic disease; deterioration; disease marker; electrostimulation; episodic migraine; ganglion; Hodgkin Huxley equation; human; ion conductance; magnetic stimulation; mathematical model; membrane potential; migraine with aura; migraine without aura; nerve cell network; neuromodulation; nonlinear system; photophobia; primary headache; priority journal; prodromal symptom; pterygopalatine ganglion; review; spreading cortical depression; superior salivatory nucleus; transcranial direct current stimulation; transcranial magnetic stimulation; transcutaneous nerve stimulation; transformed migraine
DDC: 610
License: CC BY-NC-ND 3.0 Unported
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