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Hellen et al 2011, An Electronic Analog of Synthetic Genetic Networks.pdf586,6 kBAdobe PDFView/Open
Title: An electronic analog of synthetic genetic networks
Authors: Hellen, E.H.Volkov, E.Kurths, J.Dana, S.K.
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Issue Date: 2011
Published in: PLoS ONE Vol. 6 (2011), No. 8
Publisher: San Francisco, CA : Public Library of Science (PLoS)
Abstract: An electronic analog of a synthetic genetic network known as the repressilator is proposed. The repressilator is a synthetic biological clock consisting of a cyclic inhibitory network of three negative regulatory genes which produces oscillations in the expressed protein concentrations. Compared to previous circuit analogs of the repressilator, the circuit here takes into account more accurately the kinetics of gene expression, inhibition, and protein degradation. A good agreement between circuit measurements and numerical prediction is observed. The circuit allows for easy control of the kinetic parameters thereby aiding investigations of large varieties of potential dynamics.
Keywords: article; biological rhythm; electric current; electronics; gene expression; gene regulatory network; mathematical analysis; oscillation; protein degradation; protein expression; regulator gene; repressilator; synthetic genetic network; theoretical model; Gene Expression; Gene Regulatory Networks; Models, Theoretical
DDC: 530
License: CC BY 3.0 Unported
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