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Title: Growth induction and low-oxygen apoptosis inhibition of human CD34 + progenitors in collagen gels
Authors: Avitabile, D.Salchert, K.Werner, C.Capogrossi, M.C.Pesce, M.
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Issue Date: 2013
Published in: BioMed Research International Vol. 2013 (2013)
Publisher: New York, NY : Hindawi
Abstract: Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34+ cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.
Keywords: CD34 antigen; collagen type 1; cytokine; oxygen; apoptosis; article; cell hypoxia; cell proliferation; cell protection; cell survival; controlled study; embedding; endothelial progenitor cell; human; human cell; human cell culture; hydrogel; umbilical cord blood; cell proliferation; chemistry; cytology; fetus blood; flow cytometry; metabolism; stem cell; stem cell transplantation; Antigens, CD34; Apoptosis; Cell Hypoxia; Cell Proliferation; Cell Survival; Collagen Type I; Fetal Blood; Flow Cytometry; Humans; Hydrogels; Oxygen; Stem Cell Transplantation; Stem Cells
DDC: 370
License: CC BY 3.0 Unported
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