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Title: Bio-responsive polymer hydrogels homeostatically regulate blood coagulation
Authors: Maitz, M.F.Freudenberg, U.Tsurkan, M.V.Fischer, M.Beyrich, T.Werner, C.
Publishers Version: https://doi.org/10.1038/ncomms3168
Issue Date: 2013
Published in: Nature Communications Vol. 4 (2013)
Publisher: London : Nature Publishing Group
Abstract: Bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints. Here we show that a blood coagulation-responsive hydrogel system can deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which - in turn - becomes inactivated due to released heparin. The bio-responsive hydrogel quantitatively quenches blood coagulation over several hours in the presence of pro-coagulant stimuli and during repeated incubation with fresh, non-anticoagulated blood. These features enable the introduced material to provide sustainable, autoregulated anticoagulation, addressing a key challenge of many medical therapies. Beyond that, the explored concept may facilitate the development of materials that allow the effective and controlled application of drugs and biomolecules.
Keywords: anticoagulant agent; heparin; polymer; procoagulant; thrombin; anticoagulant; bioactivity; blood; coagulation; disease treatment; enzyme activity; functional role; gel; homeostasis; medicine; molecular analysis; polymer; anticoagulation; article; blood clotting; blood transfusion; cross linking; elasticity; homeostasis; hydrogel; thrombocyte activation; Anticoagulants; Blood Coagulation; Delayed-Action Preparations; Heparin; Homeostasis; Humans; Hydrogels; Oligopeptides; Polyethylene Glycols; Polymers; Thrombin
DDC: 610
License: CC BY-NC-ND 3.0 Unported
Link to License: https://creativecommons.org/licenses/by-nc-nd/3.0/
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